Detection of linkage to affective disorders in the catalogued Amish pedigrees: A reply to Pauls et al.

Journal Article · Sat Jun 01 04:00:00 EDT 1996 · American Journal of Human Genetics

OSTI ID:446953

Gershon, E S; Goldin, L R; Badner, J A ^[1]; Berrettini, W H ^[2]

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1. National Inst. of Mental Health, Bethesda, MD (United States)
2. Thomas Jefferson Medical College, Philadelphia, PA (United States)

We have reported evidence for linkage of a region of chromosome 18 markers to affective illness in 22 bipolar (BP) pedigrees. The pedigree series included 21 US pedigrees collected by us and part of Amish pedigree 884 referred to as panel 3 in the catalog and also known as {open_quotes}the right extension.{close_quotes} The rest of 884 was never genotyped by us, because it did not fit the criteria for inclusion, as described elsewhere. Pauls et al. have recently studied whether this linkage can be detected in the entire catalogued Amish pedigrees (884 and 1075) in four of the marker loci reported. The authors conclude that the Amish data contain no significant susceptibility locus for BP illness in this region of chromosome 18. We find that the data published by Pauls et al. are not conclusive with regard to the presence or absence of any susceptibility locus under the nonparametric analyses presented, and, although the sample size is extremely small, it could also be interpreted as consistent with our findings. 17 refs., 1 tab.

• OSTI ID: 446953
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 6 Vol. 58; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOME 18
HUMAN POPULATIONS
MENTAL DISORDERS
PARAMETRIC ANALYSIS
PENNSYLVANIA
STATISTICS