Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish

Journal Article · Fri Sep 01 00:00:00 EDT 1995 · American Journal of Human Genetics

OSTI ID:110958

Pauls, D L ^[1]; Paul, S M ^[2]; Allen, C R ^[3]

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1. Yale Univ. School of Medicine, New Haven, CT (United States)
2. National Institute of Mental Health, Bethesda, MD (United States)
3. Univ. of Miami, FL (United States); and others

Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population. 40 refs., 1 fig., 5 tabs.

• OSTI ID: 110958
• Journal Information: American Journal of Human Genetics, Vol. 57, Issue 3; Other Information: PBD: Sep 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PATIENTS
HEREDITARY DISEASES
MENTAL DISORDERS
GENOTYPE
HUMAN CHROMOSOME 18
GENETIC MAPPING
ETIOLOGY
GENES
BIOLOGICAL MARKERS
STATISTICS
POLYMERASE CHAIN REACTION