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Title: Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria

Patent ·
OSTI ID:907754
 [1];  [2];  [3];  [4];  [3];  [3]
  1. Ames, IA
  2. Harbor Beach, MI
  3. Lawrence, KS
  4. St. Paul, MN
+ Show Author Affiliations

A means and method for treating bacterial infection, providing antioxidant activity, and chelating copper using a copper binding compound produced by methanotrophic bacteria is described. The compound, known as methanobactin, is the first of a new class of antibiotics having gram-positive activity. Methanobactin has been sequenced, and its structural formula determined.

Research Organization:
Iowa State Univ., Ames, IA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-96ER20237
Assignee:
The University of Kansas (Lawrence, KS); Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Number(s):
7,199,099
Application Number:
10/741,831
OSTI ID:
907754
Country of Publication:
United States
Language:
English

References (7)

Expression of soluble methane monooxygenase genes journal November 2002
Active expression of soluble methane monooxygenase from Methylosinus trichosporium OB3b in heterologous hosts journal November 2002
Methanobactin, a Copper-Acquisition Compound from Methane-Oxidizing Bacteria journal September 2004
Tissue injury by reactive oxygen species and the protective effects of flavonoids journal May 1998
Particulate methane monooxygenase from Methylosinus trichosporium is a copper-containing enzyme journal July 2002
Isolation of Copper Biochelates fromMethylosinus trichosporium OB3b and Soluble Methane Monooxygenase Mutants journal March 1998
Oxidativer Stress, altersabhängige Zellschädigungen und antioxidative Mechanismen journal April 2002

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES