Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond

Kenney, Grace E.; Rosenzweig, Amy C.

doi:10.1074/jbc.TM117.000185

Title: Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond

Journal Article · Thu Mar 01 00:00:00 EST 2018 · Journal of Biological Chemistry

DOI:https://doi.org/10.1074/jbc.TM117.000185· OSTI ID:1769431

Kenney, Grace E.; Rosenzweig, Amy C.

Methanobactins (Mbns) are ribosomally produced, post-translationally modified natural products that bind copper with high affinity and specificity. Originally identified in methanotrophic bacteria, which have a high need for copper, operons encoding these compounds have also been found in many non-methanotrophic bacteria. The proteins responsible for Mbn biosynthesis include several novel enzymes. Mbn transport involves export through a multidrug efflux pump and re-internalization via a TonB-dependent transporter. Release of copper from Mbn and the molecular basis for copper regulation of Mbn production remain to be elucidated. Finally, future work is likely to result in the identification of new enzymatic chemistry, opportunities for bioengineering and drug targeting of copper metabolism, and an expanded understanding of microbial metal homeostasis.

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Research Organization:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0016284

OSTI ID:: 1769431

Alternate ID(s):: OSTI ID: 1540313

Journal Information:: Journal of Biological Chemistry, Journal Name: Journal of Biological Chemistry Vol. 293 Journal Issue: 13; ISSN 0021-9258

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 30 works

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
biochemistry & molecular biology
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copper transport
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bacterial genetics
chalkophore
metallophore
methanobactin
RiPPs
methanotrophy

Title: Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond

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