DNA Double-Strand Breaks, Chromosomal Rearrangements, and GenomicInstability
DNA double-strand breaks can lead to chromosomalrearrangements at the first mitosis after exposure to the DNAstrand-breaking agent. The evidence suggests a number of differentpathways for DNA double-strand break rejoining in mammalian cells, but itis unclear what factors determine the fate of the induced break andwhether or not it will lead to chromosomal rearrangement. If a cell doessurvive and proliferate after DNA cleavage, delayed chromosomalinstability can be observedin the clonal descendants of the exposedcell. Most, but not all DNA double-strand breaking agents are effectiveat inducing this delayed chromosomal instability. In this paper, wereview the evidence for the role of the DNA double-strand break indirectly induced and delayed chromosomal rearrangements. Copyright 1998Elsevier Science B.V.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director, Office of Energy Research
- DOE Contract Number:
- DE-AC02-05CH11231
- OSTI ID:
- 895509
- Report Number(s):
- LBNL-41529
- Journal Information:
- Mutation Research, Vol. 404, Issue 1-2; Related Information: Journal Publication Date: 08/03/1998
- Country of Publication:
- United States
- Language:
- English
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