Comparative genome analysis of Bacillus cereus group genomes withBacillus subtilis
Genome features of the Bacillus cereus group genomes (representative strains of Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis sub spp israelensis) were analyzed and compared with the Bacillus subtilis genome. A core set of 1,381 protein families among the four Bacillus genomes, with an additional set of 933 families common to the B. cereus group, was identified. Differences in signal transduction pathways, membrane transporters, cell surface structures, cell wall, and S-layer proteins suggesting differences in their phenotype were identified. The B. cereus group has signal transduction systems including a tyrosine kinase related to two-component system histidine kinases from B. subtilis. A model for regulation of the stress responsive sigma factor sigmaB in the B. cereus group different from the well studied regulation in B. subtilis has been proposed. Despite a high degree of chromosomal synteny among these genomes, significant differences in cell wall and spore coat proteins that contribute to the survival and adaptation in specific hosts has been identified.
- Research Organization:
- Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
- Sponsoring Organization:
- USDOE Director. Office of Science. Office of Biological andEnvironmental Research, Lawrence Livermore National Laboratory, LosAlamos National Laboratory; Department of Defense. Defense AdvancedResearch Projects Agency Grant DAAH01-99-C-$208, Integrated Genomics Inc,French National Institute for Agricultural Research
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 891027
- Report Number(s):
- LBNL--58211; BnR: KP1103010
- Journal Information:
- FEMS Microbiology Letters, Journal Name: FEMS Microbiology Letters Journal Issue: 2 Vol. 250; ISSN 0378-1097; ISSN FMLED7
- Country of Publication:
- United States
- Language:
- English
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