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Title: The Pathogenomic Sequence Analysis of B. cereus and B.thuringiensis Isolates Closely Related to Bacillus anthracis

Abstract

The sequencing and analysis of two close relatives of Bacillus anthracis are reported. AFLP analysis of over 300 isolates of B.cereus, B. thuringiensis and B. anthracis identified two isolates as being very closely related to B. anthracis. One, a B. cereus, BcE33L, was isolated from a zebra carcass in Nambia; the second, a B. thuringiensis, 97-27, was isolated from a necrotic human wound. The B. cereus appears to be the closest anthracis relative sequenced to date. A core genome of over 3,900 genes was compiled for the Bacillus cereus group, including Banthracis. Comparative analysis of these two genomes with other members of the B. cereus group provides insight into the evolutionary relationships among these organisms. Evidence is presented that differential regulation modulates virulence, rather than simple acquisition of virulence factors. These genome sequences provide insight into the molecular mechanisms contributing to the host range and virulence of this group of organisms.

Authors:
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Publication Date:
Research Org.:
Ernest Orlando Lawrence Berkeley NationalLaboratory, Berkeley, CA (US)
Sponsoring Org.:
USDOE Director. Office of Science. Office of Biological andEnvironmental Research
OSTI Identifier:
881606
Report Number(s):
LBNL-58996
Journal ID: ISSN 0021-9193; JOBAAY; R&D Project: 626880; BnR: KP1103010; TRN: US200612%%914
DOE Contract Number:  
DE-AC02-05CH11231
Resource Type:
Journal Article
Journal Name:
Journal of Bacteriology
Additional Journal Information:
Journal Volume: 188; Journal Issue: 9; Related Information: Journal Publication Date: 05/2006; Journal ID: ISSN 0021-9193
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BACILLUS; BACILLUS CEREUS; GENES; REGULATIONS; STRUCTURAL CHEMICAL ANALYSIS; VIRULENCE; Comparative analysis genomics evolution virulence opportunisticpathogen

Citation Formats

Han, Cliff S, Xie, Gary, Challacombe, Jean F, Altherr, MichaelR, Smriti, B, Bruce, David, Campbell, Connie S, Campbell, Mary L, Chen, Jin, Chertkov, Olga, Cleland, Cathy, Dimitrijevic-Bussod, M, Doggett, Norman A, Fawcett, John J, Glavina, Tijana, Goodwin, Lynne A, Hill, Karen K, Hitchcock, Penny, Jackson, Paul J, Keim, Paul, Kewalramani, Avinash Ramesh, Longmire, Jon, Lucas, Susan, Malfatti, Stephanie, McMurry, Kim, Meincke, Linda J, Misra, Monica, Moseman, Bernice L, Mundt, Mark, Munk, A Christine, Okinaka, Richard T, Parson-Quintana, B, Reilly, Lee P, Richardson, Paul, Robinson, DonnaL, Rubin, Eddy, Saunders, Elizabeth, Tapia, Roxanne, Tesmer, Judith G, Thayer, Nina, Thompson, Linda S, Tice, Hope, Ticknor, Lawrence O, Wills, Patti L, Gilna, Payl, and Brettin, Thomas S. The Pathogenomic Sequence Analysis of B. cereus and B.thuringiensis Isolates Closely Related to Bacillus anthracis. United States: N. p., 2005. Web.
Han, Cliff S, Xie, Gary, Challacombe, Jean F, Altherr, MichaelR, Smriti, B, Bruce, David, Campbell, Connie S, Campbell, Mary L, Chen, Jin, Chertkov, Olga, Cleland, Cathy, Dimitrijevic-Bussod, M, Doggett, Norman A, Fawcett, John J, Glavina, Tijana, Goodwin, Lynne A, Hill, Karen K, Hitchcock, Penny, Jackson, Paul J, Keim, Paul, Kewalramani, Avinash Ramesh, Longmire, Jon, Lucas, Susan, Malfatti, Stephanie, McMurry, Kim, Meincke, Linda J, Misra, Monica, Moseman, Bernice L, Mundt, Mark, Munk, A Christine, Okinaka, Richard T, Parson-Quintana, B, Reilly, Lee P, Richardson, Paul, Robinson, DonnaL, Rubin, Eddy, Saunders, Elizabeth, Tapia, Roxanne, Tesmer, Judith G, Thayer, Nina, Thompson, Linda S, Tice, Hope, Ticknor, Lawrence O, Wills, Patti L, Gilna, Payl, & Brettin, Thomas S. The Pathogenomic Sequence Analysis of B. cereus and B.thuringiensis Isolates Closely Related to Bacillus anthracis. United States.
Han, Cliff S, Xie, Gary, Challacombe, Jean F, Altherr, MichaelR, Smriti, B, Bruce, David, Campbell, Connie S, Campbell, Mary L, Chen, Jin, Chertkov, Olga, Cleland, Cathy, Dimitrijevic-Bussod, M, Doggett, Norman A, Fawcett, John J, Glavina, Tijana, Goodwin, Lynne A, Hill, Karen K, Hitchcock, Penny, Jackson, Paul J, Keim, Paul, Kewalramani, Avinash Ramesh, Longmire, Jon, Lucas, Susan, Malfatti, Stephanie, McMurry, Kim, Meincke, Linda J, Misra, Monica, Moseman, Bernice L, Mundt, Mark, Munk, A Christine, Okinaka, Richard T, Parson-Quintana, B, Reilly, Lee P, Richardson, Paul, Robinson, DonnaL, Rubin, Eddy, Saunders, Elizabeth, Tapia, Roxanne, Tesmer, Judith G, Thayer, Nina, Thompson, Linda S, Tice, Hope, Ticknor, Lawrence O, Wills, Patti L, Gilna, Payl, and Brettin, Thomas S. Thu . "The Pathogenomic Sequence Analysis of B. cereus and B.thuringiensis Isolates Closely Related to Bacillus anthracis". United States. https://www.osti.gov/servlets/purl/881606.
@article{osti_881606,
title = {The Pathogenomic Sequence Analysis of B. cereus and B.thuringiensis Isolates Closely Related to Bacillus anthracis},
author = {Han, Cliff S and Xie, Gary and Challacombe, Jean F and Altherr, MichaelR and Smriti, B and Bruce, David and Campbell, Connie S and Campbell, Mary L and Chen, Jin and Chertkov, Olga and Cleland, Cathy and Dimitrijevic-Bussod, M and Doggett, Norman A and Fawcett, John J and Glavina, Tijana and Goodwin, Lynne A and Hill, Karen K and Hitchcock, Penny and Jackson, Paul J and Keim, Paul and Kewalramani, Avinash Ramesh and Longmire, Jon and Lucas, Susan and Malfatti, Stephanie and McMurry, Kim and Meincke, Linda J and Misra, Monica and Moseman, Bernice L and Mundt, Mark and Munk, A Christine and Okinaka, Richard T and Parson-Quintana, B and Reilly, Lee P and Richardson, Paul and Robinson, DonnaL and Rubin, Eddy and Saunders, Elizabeth and Tapia, Roxanne and Tesmer, Judith G and Thayer, Nina and Thompson, Linda S and Tice, Hope and Ticknor, Lawrence O and Wills, Patti L and Gilna, Payl and Brettin, Thomas S},
abstractNote = {The sequencing and analysis of two close relatives of Bacillus anthracis are reported. AFLP analysis of over 300 isolates of B.cereus, B. thuringiensis and B. anthracis identified two isolates as being very closely related to B. anthracis. One, a B. cereus, BcE33L, was isolated from a zebra carcass in Nambia; the second, a B. thuringiensis, 97-27, was isolated from a necrotic human wound. The B. cereus appears to be the closest anthracis relative sequenced to date. A core genome of over 3,900 genes was compiled for the Bacillus cereus group, including Banthracis. Comparative analysis of these two genomes with other members of the B. cereus group provides insight into the evolutionary relationships among these organisms. Evidence is presented that differential regulation modulates virulence, rather than simple acquisition of virulence factors. These genome sequences provide insight into the molecular mechanisms contributing to the host range and virulence of this group of organisms.},
doi = {},
journal = {Journal of Bacteriology},
issn = {0021-9193},
number = 9,
volume = 188,
place = {United States},
year = {2005},
month = {8}
}