Adsorption of biometals to monosodium titanate in biological environments

Journal Article · Mon Jun 06 04:00:00 EDT 2005

OSTI ID:881362

HOBBS, D T; MESSER, R L. W.; LEWIS, J B; WATAHA, J C

Monosodium titanate (MST) is an inorganic sorbent/ion exchanger developed for the removal of radionuclides from nuclear wastes. We investigated the ability of MST to bind Cd(II), Hg(II), or Au(III) to establish the utility of MST for applications in environmental decontamination or medical therapy (drug delivery). Adsorption isotherms for MST were determined at pH 7-7.5 in water or phosphate-buffered saline. The extent of metal binding was determined spectroscopically by measuring the concentrations of the metals in solution before and after contact with the MST. Cytotoxic responses to MST were assessed using THP1 monocytes and succinate dehydrogenase activity. Monocytic activation by MST was assessed by TNF{alpha} secretion (ELISA) with or without lipopolysaccharide (LPS) activation. MST sorbed Cd(II), Hg(II), and Au(III) under conditions similar to that in physiological systems. MST exhibited the highest affinity for Cd(II) followed by Hg(II) and Au (III). MST (up to 100 mg/L) exhibited only minor (< 25% suppression of succinate dehydrogenase) cytotoxicity and did not trigger TNF{alpha} secretion nor modulate LPS-induced TNF{alpha} secretion from monocytes. MST exhibits high affinity for biometals with no significant biological liabilities in these introductory studies. MST deserves further scrutiny as a substance with the capacity to decontaminate biological environments or deliver metals in a controlled fashion.

• Research Organization: Savannah River Site (SRS), Aiken, SC
• Sponsoring Organization: USDOE
• DOE Contract Number: AC09-96SR18500
• OSTI ID: 881362
• Report Number(s): WSRC-MS-2005-00346
• Country of Publication: United States
• Language: English

Related Subjects

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE WASTES FROM NUCLEAR FACILITIES
ADSORPTION
ADSORPTION ISOTHERMS
AFFINITY
DECONTAMINATION
ENZYME IMMUNOASSAY
LIPOPOLYSACCHARIDES
MONOCYTES
OXIDOREDUCTASES
RADIOACTIVE WASTES
RADIOISOTOPES
REMOVAL
SECRETION
THERAPY
TITANATES
WATER