A Biomimetic Approach to Discrimination Between Sequential and Concerted Models for the Oxidation of Ubiquinol at the Qo­ site of the Cyt bc1 Complex

Conference · Mon Sep 26 00:00:00 EDT 2005

OSTI ID:877038

Cape, Jonathan L; Forquer, Isaac P; Bowman, Michael K; Kramer, David M

The cytochrome bc complexes function as quinol:cytochrome c oxidoreductases in the energy conserving membranes of nearly all organisms, where they couple the oxidation of a quinol substrate (QH2) to the pumping of protons across the bioenergetic membrane, resulting in the establishment of a proton motive force, which is used to drive the (C)F0/(C)F1 ATP synthase (Trumpower and Gennis 1994). Among the variety of biological quinols characterized, ubiquinol is the substrate used by most bc-type complexes, and its reactions are of great interest concerning diseases related to oxidative stress and the fundamentals of biological energy transduction.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 877038
• Report Number(s): PNNL-SA-45294; 2358a; KP1704020; TRN: US0601581
• Resource Relation: Conference: Photosynthesis : fundamental aspects to global perspectives : proceedings of the 13th International Congress on Photosynthesis, Montreal 2004, 1095-1097
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
CYTOCHROMES
DISEASES
MEMBRANES
OXIDATION
OXIDOREDUCTASES
PHOTOSYNTHESIS
PROTONS
PUMPING
SUBSTRATES
Environmental Molecular Sciences Laboratory