Process for the manufacture of 117Sn diethylenetriaminepentaacetic acids

Patent · Wed Jan 01 00:00:00 EST 2003

OSTI ID:875137

Srivastava, Suresh C ^[1]; Li, Zizhong ^[2]; Meinken, George ^[3]

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1. Setauket, NY
2. Upton, NY
3. Middle Island, NY

Novel methods are provided for the manufacture of .sup.117m Sn(Sn.sup.4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to .sup.117m Sn(Sn.sup.4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.

• Research Organization: Brookhaven National Laboratory (BNL), Upton, NY (United States)
• DOE Contract Number: AC02-98CH10886
• Assignee: Brookhaven Science Associates, LLC (Upton, NY)
• Patent Number(s): US 6541514
• OSTI ID: 875137
• Country of Publication: United States
• Language: English

Related Subjects

process
manufacture
117sn
diethylenetriaminepentaacetic
acids
novel
methods
provided
sup117m
snsnsup4
dtpa
method
allows
toxic
chelating
agent
approximately
11
ratio
via
aqueous
conditions
organic
solvents
methylene
chloride
pharmaceutical
composition
manufactured
treatment
bone
tumors
pain
associated
cancer
organic solvent
chelating agent
acetic acid
/514/424/999/600/