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Microfabricated AC impedance sensor

Patent ·
OSTI ID:874672
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [6];  [9]
  1. Pleasanton, CA
  2. Sunnyvale, CA
  3. Houston, TX
  4. Berkeley, CA
  5. Austin, TX
  6. Livermore, CA
  7. Bellaire, TX
  8. Tracy, CA
  9. San Diego, CA
+ Show Author Affiliations
A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.
Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
DOE Contract Number:
W-7405-ENG-48
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
US 6437551
OSTI ID:
874672
Country of Publication:
United States
Language:
English

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Related Subjects

/324/436/
alternating
alternating current
applications
appropriate
associated
based
cell
cells
chip
circuits
clinical
connect
critical
current
detect
detecting
detection
diagnostic
electrical
electrodes
elements
enable
environmental
glass
glass substrate
identify
identifying
impedance
individual
instrument
measurements
microchannel
microchannels
microfabricated
microfluidic
multiple
particle
particles
patterned
rates
resolution
sensor
signals
substrates
sufficient
throughput
traveling
types