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Micromechanical antibody sensor

Patent ·
OSTI ID:873996
 [1];  [2];  [1];  [2];  [1]
  1. Knoxville, TN
  2. Oak Ridge, TN
+ Show Author Affiliations
A sensor apparatus is provided using a microcantilevered spring element having a coating of a detector molecule such as an antibody or antigen. A sample containing a target molecule or substrate is provided to the coating. The spring element bends in response to the stress induced by the binding which occurs between the detector and target molecules. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers.
Research Organization:
LOCKHEED MARTIN ENERGY RES COR
DOE Contract Number:
AC05-96OR22464
Assignee:
U. T. Battelle, LLC (Oak Ridge, TN)
Patent Number(s):
US 6289717
OSTI ID:
873996
Country of Publication:
United States
Language:
English

References (10)

Observation of a chemical reaction using a micromechanical sensor journal January 1994
A mechanical nanosensor in the gigahertz range: where mechanics meets electronics journal January 1994
Sensing Discrete Streptavidin-Biotin Interactions with Atomic Force Microscopy journal February 1994
Photothermal spectroscopy with femtojoule sensitivity using a micromechanical device journal November 1994
Detection of mercury vapor using resonating microcantilevers journal March 1995
A nondestructive method for determining the spring constant of cantilevers for scanning force microscopy journal February 1993
Viscous drag measurements utilizing microfabricated cantilevers journal June 1996
Uncooled thermal imaging using a piezoresistive microcantilever journal November 1996
Microcantilever Sensors journal July 1997
Microfabrication of cantilever styli for the atomic force microscope
  • Albrecht, T. R.; Akamine, S.; Carver, T. E.
  • Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, Vol. 8, Issue 4 https://doi.org/10.1116/1.576520
journal July 1990

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Related Subjects

/73/422/436/
01
200
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antibody
antigen
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cantilever
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occurs
provided
range
response
sample
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sensitivity
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sensor apparatus
spring
spring element
stress
stress induced
substrate
target
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techniques
thick
variety
wide