Method for measuring lead concentrations in blood

Nogar, Nicholas S

Method for measuring lead concentrations in blood

Patent · Sun Dec 31 23:00:00 EST 2000

OSTI ID:873797

Nogar, Nicholas S ^[1]

Los Alamos, NM

Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.

View Patent

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM

DOE Contract Number:: W-7405-ENG-36

Assignee:: Regents of University of California (Los Alamos, MX)

Patent Number(s):: US 6248592

OSTI ID:: 873797

Country of Publication:: United States

Language:: English

References (15)

Need for better tests for lead in blood is urgent Ember, Lois Chemical & Engineering News, Vol. 71, Issue 43 https://doi.org/10.1021/cen-v071n043.p007	journal	October 1993
Sample preparation technique for the analysis of vegetative bacteria cells of the genus bacillus with the laser microprobe mass analyzer (LAMMA) Böhm, R. Fresenius' Zeitschrift für analytische Chemie, Vol. 308, Issue 3 https://doi.org/10.1007/BF00479636	journal	January 1981
Laser-enhanced ionisation spectrometry following matrix modification by automated chelation chromatography for the analysis of biological and environmental reference materials Turk, Gregory C.; Kingston, H. M. Journal of Analytical Atomic Spectrometry, Vol. 5, Issue 7 https://doi.org/10.1039/ja9900500595	journal	January 1990
The distribution of lead in human hemopoietic tissue and spongy bone after lead poisoning and Ca-EDTA chelation therapy: Observations made by atomic absorption spectroscopy, laser microbeam mass analysis and electron microbeam X-ray analysis Flood, Per R.; Schmidt, Peter Fritz; Wesenberg, Gro R. Archives of Toxicology, Vol. 62, Issue 4 https://doi.org/10.1007/BF00332490	journal	October 1988
Resonant Laser Ablation: Semiquantitative Aspects and Threshold Effects Eiden, G. C.; Anderson, J. E.; Nogar, N. S. Microchemical Journal, Vol. 50, Issue 3 https://doi.org/10.1006/mchj.1994.1095	journal	December 1994
Resonant laser ablation—a novel surface analytic technique Borthwick, I. S.; Ledingham, K. W. D.; Singhal, R. P. Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 47, Issue 11 https://doi.org/10.1016/0584-8547(92)80117-Y	journal	October 1992
Pulsed laser resonance ionization mass spectrometry for elementally selective detection of lead and bismuth mixtures Fearey, B. L.; Miller, Charles M.; Rowe, M. W. Analytical Chemistry, Vol. 60, Issue 17 https://doi.org/10.1021/ac00168a028	journal	September 1988
LAMMA 500 principle and technical description of the instrument Vogt, H.; Heinen, H. J.; Meier, S. Fresenius' Zeitschrift für analytische Chemie, Vol. 308, Issue 3 https://doi.org/10.1007/BF00479623	journal	January 1981
Direct determination of lead in blood by laser-excited flame atomic-fluorescence spectrometry Omenetto, Nicolo; Human, Hendricks G. C.; Cavalli, Paulo The Analyst, Vol. 109, Issue 8 https://doi.org/10.1039/an9840901067	journal	January 1984
A high-sensitivity laser microprobe mass analyzer Hillenkamp, F.; Unsöld, E.; Kaufmann, R. Applied Physics, Vol. 8, Issue 4 https://doi.org/10.1007/BF00898368	journal	December 1975
Chromium detection by laser desorption and resonance ionization mass spectrometry Nogar, N. S.; Estler, R. C. Analytical Chemistry, Vol. 64, Issue 5 https://doi.org/10.1021/ac00029a003	journal	March 1992
Laser desorption mass spectrometry of nonvolatiles under shock wave conditions Lindner, Buko.; Seydel, Ulrich. Analytical Chemistry, Vol. 57, Issue 4 https://doi.org/10.1021/ac00281a027	journal	April 1985
Multi-elemental analysis of environmental matrices by laser ablation inductively coupled plasma mass spectrometry Durrant, Steven F. The Analyst, Vol. 117, Issue 10 https://doi.org/10.1039/an9921701585	journal	January 1992
Monitoring human exposure to lead: An assessment of current laboratory performance for the determination of blood lead Parsons, Patrick J. Environmental Research, Vol. 57, Issue 2 https://doi.org/10.1016/S0013-9351(05)80075-1	journal	April 1992
Comparison of Laser and Ion Microprobe Detection Sensitivity for Lead in Biological Microanalysis Linton, Richard W.; Bryan, Scott R.; Schmidt, Peter F. Analytical Chemistry, Vol. 57, Issue 2 https://doi.org/10.1021/ac50001a027	journal	February 1985

Similar Records

Blood lead levels of South African long-distance road-runners

Journal Article · Thu May 01 00:00:00 EDT 1986 · Arch. Environ. Health; (United States) · OSTI ID:5113112

Resonant laser ablation: Applications and mechanistic aspects

Conference · Sat Dec 30 23:00:00 EST 1995 · OSTI ID:188557

Environmental trace analysis by ion trap mass spectrometry

Conference · Sat Dec 30 23:00:00 EST 1995 · OSTI ID:466544

Related Subjects

/436/
10
ablation
analyte
analyze
analyzed
atomizes
beam
blood
collected
concentrations
conducting
conducting substrate
content
detected
electrically
electrically conducting
equivalent
example
finger
focused
focused laser
ionizes
irradiated
laser
laser ablation
laser beam
lead
lead concentrations
lead content
lead-free
ltoreq
mass
mass spectrometer
measuring
measuring lead
method
placed
prick
readily
resonant
resonant laser
resonantly
sample
samples
simultaneously
single
solid
solid sample
sorted
spectrometer
substrate
typical
vaporizes
yields

Method for measuring lead concentrations in blood

Citation Formats

References (15)

Similar Records

Related Subjects