Pyrrolo isoquinolines

Patent · Sat Jan 01 04:00:00 EST 2000

OSTI ID:873450

Goodman, Mark M ^[1]; Shi, Bing Z ^[2]

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1. Atlanta, GA
2. Cincinnati, OH

Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I, .sup.75 Br, .sup.76 Br, .sup.77 Br, .sup.82 Br, .sup.18 F, or .sup.210 At; small alkyl, small alkenyl, or small alkynyl, any of which contains from one to about six carbon atoms and optionally having a carbon atom replaced by an O or S; or halogen substituted-small alkyl, halogen substituted-small alkenyl, or halogen substituted-small alkynyl wherein said compound contains at least one radioacitve halogen. The compounds bind to the serotonin transporter. Depending upon the choice of halogen substituent, the compounds are useful for PET or SPECT imaging, diagnosis and treatment of psychiatric disorders such as depression, anxiety, obsessive-compulsive disorder, and other conditions associated with defects of serotonin transporter function.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA
• Assignee: Emory University (Atlanta, GA)
• Patent Number(s): US 6162417
• OSTI ID: 873450
• Country of Publication: United States
• Language: English

Related Subjects

/424/999/
123
124
125
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82
alkenyl
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alkynyl
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atom
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choice
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six
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