Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives thereof

Patent · Fri Dec 31 23:00:00 EST 1999

OSTI ID:873072

Hollingsworth, Rawle I ^[1]; Wang, Guijun ^[2]

---

1. Haslett, MI
2. East Lansing, MI

A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl)trialkylammonium salts, particularly in chiral form is described. Furthermore, a process is described wherein the (2,2-dimethyl-1,3-dioxolan-4ylmethyl)trialkylammonium salts is a 2,2-dimethyl-1,3-dioxolan-4-ylmethyl trimethylammonium salt, preferably in chiral form. The protected dihydroxypropyl trialkylammonium salts lead to L-carnitine (9) when in chiral form (5).

• Research Organization: Michigan State University
• DOE Contract Number: FG02-89ER14029
• Assignee: Board of Trustees operating Michigan State University (East Lansing, MI)
• Patent Number(s): US 6084131
• OSTI ID: 873072
• Country of Publication: United States
• Language: English

Related Subjects

/999/
2-dimethyl-1
3-dioxolan-4-ylmethyl
3-dioxolan-4ylmethyl
ammonium salt
ammonium salts
chiral
chiral form
derivatives
described
dihydroxypropyl
dihydroxypropyl trialkylammonium
form
furthermore
l-carnitine
lead
particular
particularly
preferably
preparation
process
protected
protected dihydroxypropyl
salt
salts
trialkylammonium
trialkylammonium salts
trimethylammonium