Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof

Hollingsworth, Rawle I; Wang, Guijun

Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof

Patent · Fri Dec 31 23:00:00 EST 1999

OSTI ID:872924

Hollingsworth, Rawle I ^[1]; Wang, Guijun ^[2]

Haslett, MI
East Lansing, MI

A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,2-dihydroxypropane isopropylidene acetal. The protected 3-amino-1,2-dihydroxypropane acetal is a key intermediate to the preparation of chiral 3-carbon compounds which in turn are intermediates to various pharmaceuticals.

Research Organization:: Michigan State University

DOE Contract Number:: FG02-89ER14029

Assignee:: Board of Trustees operating Michigan State University (East Lansing, MI)

Patent Number(s):: US 6040464

OSTI ID:: 872924

Country of Publication:: United States

Language:: English

References (6)

Stereospecific Synthesis of Thioether Glycerophospholipids. Catalytic Asymmetric Epoxidation Followed by in situ Borohydride-Mediated Opening of Glycidol with Hexadecylmercaptan Byun, Hoe-Sup; Bittman, Robert The Journal of Organic Chemistry, Vol. 59, Issue 3 https://doi.org/10.1021/jo00082a030	journal	February 1994
Membrane-enclosed enzymic catalysis (MEEC): a useful, practical new method for the manipulation of enzymes in organic synthesis Bednarski, Mark D.; Chenault, H. Keith; Simon, Ethan S. Journal of the American Chemical Society, Vol. 109, Issue 4 https://doi.org/10.1021/ja00238a067	journal	February 1987
Synthese und Struktur diastereomerenreiner 2,6-disubstituierter 3-Morpholinone Danklmaier, Johann; Hönig, Helmut Liebigs Annalen der Chemie, Vol. 1988, Issue 12 https://doi.org/10.1002/jlac.198819881208	journal	December 1988
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral .beta.-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene Baldwin, John J.; McClure, David E.; Gross, Dennis M. Journal of Medicinal Chemistry, Vol. 25, Issue 8 https://doi.org/10.1021/jm00350a009	journal	August 1982
Substrate specificity and enantioselectivity of penicillinacylase catalyzed hydrolysis of phenacetyl esters of synthetically useful carbinols Fuganti, Claudio; Grasselli, Piero; Servi, Stefano Tetrahedron, Vol. 44, Issue 9 https://doi.org/10.1016/S0040-4020(01)81708-7	journal	January 1988
A direct HPLC method for the determination of enantiomeric excess of some highly enantiomerically enriched derivatives of chiral glycidols Chen, Jian; Shum, Wilfred Tetrahedron Letters, Vol. 34, Issue 48 https://doi.org/10.1016/S0040-4039(00)61533-2	journal	November 1993

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Related Subjects

/999/
2-dihydroxypropane
3-amino-1
3-carbon
acetal
carbon compound
carbon compounds
chiral
chiral form
compounds
derivatives
forms
intermediate
intermediates
isopropylidene
key
particular
particularly
pharmaceuticals
preparation
process
producing
protected
relates
various

Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof

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References (6)

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