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Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Patent ·
OSTI ID:872792
 [1]
  1. Knoxville, TN
+ Show Author Affiliations

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Research Organization:
LOCKHEED MARTIN ENRGY SYST INC
DOE Contract Number:
AC05-84OR21400
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
Patent Number(s):
US 6010607
OSTI ID:
872792
Country of Publication:
United States
Language:
English

References (10)

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis journal June 1994
Electric sample splitter for capillary zone electrophoresis journal February 1985
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip journal August 1993
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices journal April 1994
Capillary electrophoresis and sample injection systems integrated on a planar glass chip journal September 1992
Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency journal May 1993
Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections journal January 1994
Micromachining of monocrystalline silicon and glass for chemical analysis systems A look into next century's technology or just a fashionable craze? journal May 1991
High-Speed Separations on a Microchip journal April 1994
Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights journal October 1993

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