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Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media

Patent ·
OSTI ID:872695
 [1];  [2];  [2]
  1. Laguna Niguel, CA
  2. Irvine, CA
+ Show Author Affiliations
Optical Doppler tomography permits imaging of fluid flow velocity in highly scattering media. The tomography system combines Doppler velocimetry with high spatial resolution of partially coherent optical interferometry to measure fluid flow velocity at discrete spatial locations. Noninvasive in vivo imaging of blood flow dynamics and tissue structures with high spatial resolutions of the order of 2 to 10 microns is achieved in biological systems. The backscattered interference signals derived from the interferometer may be analyzed either through power spectrum determination to obtain the position and velocity of each particle in the fluid flow sample at each pixel, or the interference spectral density may be analyzed at each frequency in the spectrum to obtain the positions and velocities of the particles in a cross-section to which the interference spectral density corresponds. The realized resolutions of optical Doppler tomography allows noninvasive in vivo imaging of both blood microcirculation and tissue structure surrounding the vessel which has significance for biomedical research and clinical applications.
Research Organization:
University of California
DOE Contract Number:
FG03-91ER61227
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5991697
OSTI ID:
872695
Country of Publication:
United States
Language:
English

References (8)

Distributed laser Doppler velocimeter journal January 1991
Optical Doppler Tomography: Imaging in vivo Blood Flow Dynamics Following Pharmacological Intervention and Photodynamic Therapy journal January 1998
Optical coherence tomography with the "spectral radar": fast optical analysis in volume scatterers by short-coherence interferometry conference December 1996
Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media journal January 1997
Optical coherence tomography journal November 1991
Optical low-coherence reflectometry to enhance monte Carlo modeling of skin journal January 1997
Characterization of fluid flow velocity by optical Doppler tomography journal January 1995
Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography journal January 1997

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/702/356/382/600/
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