{ital In vivo} bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography

Journal Article · Mon Sep 01 04:00:00 EDT 1997 · Optics Letters

DOI:https://doi.org/10.1364/OL.22.001439· OSTI ID:560688

Izatt, J A; Kulkarni, M D; Yazdanfar, S ^[1]; Barton, J K; Welch, A J ^[2]

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1. Departments of Biomedical Engineering and Medicine, Case Western Reserve University, Cleveland, Ohio 44106 (United States)
2. Biomedical Engineering Program, University of Texas at Austin, Austin, Texas 78712 (United States)

We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for {ital in vivo} imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with {lt}50{minus}{mu}m spatial resolution and {lt}0.6{minus}mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications. {copyright} {ital 1997} {ital Optical Society of America}

• DOE Contract Number: FG03-95ER61971
• OSTI ID: 560688
• Journal Information: Optics Letters, Journal Name: Optics Letters Journal Issue: 18 Vol. 22; ISSN OPLEDP; ISSN 0146-9592
• Country of Publication: United States
• Language: English

Related Subjects

44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
BLOOD FLOW
FLOW VISUALIZATION
IN VIVO
INTERFEROMETRY
MEDICINE
OPTICAL EQUIPMENT
TOMOGRAPHY
TURBIDITY