Electrochemical detector integrated on microfabricated capillary electrophoresis chips

Mathies, Richard A; Glazer, Alexander N; Lao, Kaiqin; Woolley, Adam T

Electrochemical detector integrated on microfabricated capillary electrophoresis chips

Patent · Fri Jan 01 04:00:00 EST 1999

OSTI ID:872297

Mathies, Richard A ^[1]; Glazer, Alexander N ^[2]; Lao, Kaiqin ^[3]; Woolley, Adam T ^[4]

Moraga, CA
Orinda, CA
San Francisco, CA
Albany, CA

A microfabricated capillary electrophoresis chip which includes an integral thin film electrochemical detector for detecting molecules separated in the capillary.

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Research Organization:: University of California

DOE Contract Number:: FG03-91ER61125

Assignee:: Regents of University of California (Berkeley, CA)

Patent Number(s):: US 5906723

OSTI ID:: 872297

Country of Publication:: United States

Language:: English

References (17)

Electrochemical Measurement of the Solvent Accessibility of Nucleobases Using Electron Transfer between DNA and Metal Complexes Johnston, Dean H.; Glasgow, Katherine C.; Thorp, H. Holden Journal of the American Chemical Society, Vol. 117, Issue 35 https://doi.org/10.1021/ja00140a006	journal	September 1995
Capillary electrophoresis with electrochemical detection employing an on-column Nafion joint O'Shea, Thomas J.; Greenhagen, Robin D.; Lunte, Susan M. Journal of Chromatography A, Vol. 593, Issue 1-2 https://doi.org/10.1016/0021-9673(92)80299-A	journal	February 1992
Capillary electrophoresis in 2 and 5 .mu.m diameter capillaries: application to cytoplasmic analysis Olefirowicz, Teresa M.; Ewing, Andrew G. Analytical Chemistry, Vol. 62, Issue 17 https://doi.org/10.1021/ac00216a026	journal	September 1990
Electrochemically Active DNA Probes: Detection of Target DNA Sequences at Femtomole Level by High-Performance Liquid Chromatography with Electrochemical Detection Takenaka, S.; Uto, Y.; Kondo, H. Analytical Biochemistry, Vol. 218, Issue 2 https://doi.org/10.1006/abio.1994.1203	journal	May 1994
On-column conductivity detector for capillary zone electrophoresis Huang, Xiaohua.; Pang, Teng Ke J.; Gordon, Manuel J. Analytical Chemistry, Vol. 59, Issue 23 https://doi.org/10.1021/ac00150a004	journal	December 1987
An Electrochemical Cell for End-Column Amperometric Detection in Capillary Electrophoresis Chen, Mei-Cheng.; Huang, Hsuan-Jung. Analytical Chemistry, Vol. 67, Issue 21 https://doi.org/10.1021/ac00117a030	journal	November 1995
Electrochemical detection in microcolumn separations Ewing, Andrew G.; Mesaros, Jody M.; Gavin, Peter F. Analytical Chemistry, Vol. 66, Issue 9 https://doi.org/10.1021/ac00081a002	journal	April 1994
Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips. Woolley, A. T.; Mathies, R. A. Proceedings of the National Academy of Sciences, Vol. 91, Issue 24 https://doi.org/10.1073/pnas.91.24.11348	journal	November 1994
Electrophoretically mediated micro-assay of alkaline phosphatase using electrochemical and spectrophotometric detection in capillary electrophoresis Wu, Dan; Regnier, Fred E.; Linhares, Michael C. Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 657, Issue 2 https://doi.org/10.1016/0378-4347(94)00140-5	journal	July 1994
[54] In Vivo Oxidative DNA damage: Measurement of 8-Hydroxy-2′-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection Shigenaga, Mark K.; Park, Jeen-Woo; Cundy, Kenneth C. Oxygen Radicals in Biological Systems Part B: Oxygen Radicals and Antioxidants https://doi.org/10.1016/0076-6879(90)86146-M	book	January 1990
End-column detection for capillary zone electrophoresis Huang, Xiaohua.; Zare, Richard N.; Sloss, Sandra. Analytical Chemistry, Vol. 63, Issue 2 https://doi.org/10.1021/ac00002a020	journal	January 1991
Electrochemical detection of histamine and 5-hydroxytryptamine at isolated mast cells Pihel, Karin.; Hsieh, Showchien.; Jorgenson, James W. Analytical Chemistry, Vol. 67, Issue 24 https://doi.org/10.1021/ac00120a014	journal	December 1995
Second Harmonic Alternating Current Polarography with a Reversible Electrode Process Smith, D. E.; Reinmuth, W. H. Analytical Chemistry, Vol. 33, Issue 4 https://doi.org/10.1021/ac60172a002	journal	April 1961
Continuous Separations with Microfabricated Electrophoresis−Electrochemical Array Detection Gavin, Peter F.; Ewing, Andrew G. Journal of the American Chemical Society, Vol. 118, Issue 37 https://doi.org/10.1021/ja961368s	journal	January 1996
On-chip microband array electrochemical detector for use in capillary electrophoresis Slater, Jonathan M.; Watt, Esther J. The Analyst, Vol. 119, Issue 11 https://doi.org/10.1039/an9941902303	journal	January 1994
Electrochemical Detection of Single Molecules Fan, F. -R. F.; Bard, A. J. Science, Vol. 267, Issue 5199 https://doi.org/10.1126/science.267.5199.871	journal	February 1995
Ultra-High-Speed DNA Sequencing Using Capillary Electrophoresis Chips Woolley, Adam T.; Mathies, Richard A. Analytical Chemistry, Vol. 67, Issue 20 https://doi.org/10.1021/ac00116a010	journal	October 1995

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/204/
capillary
capillary electrophoresis
chip
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detector
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electrochemical
electrochemical detector
electrophoresis
electrophoresis chip
electrophoresis chips
film
film electrochemical
integral
integrated
microfabricated
microfabricated capillary
molecules
molecules separated
separated

Electrochemical detector integrated on microfabricated capillary electrophoresis chips

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