Method for quantifying optical properties of the human lens

Patent · Fri Jan 01 04:00:00 EST 1999

OSTI ID:872253

Bigio, Irving J ^[1]; Zuclich, Joseph A ^[2]; Shimada, Tsutomu ^[1]; Strobl, Karlheinz ^[3]

---

1. Los Alamos, NM
2. San Antonio, TX
3. Fiskdale, MA

Method for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject's chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• DOE Contract Number: W-7405-ENG-36
• Assignee: Regents of University of California (Los Alamos, NM)
• Patent Number(s): US 5894340
• OSTI ID: 872253
• Country of Publication: United States
• Language: English

Related Subjects

/351/
300-
600-nm
900-nm
accelerated
age
ages
aging
application
assess
assessment
backscatter
cataract
characteristics
chronological
collected
comparing
comprehensive
database
described
diagnostic
diagnostic tool
disease
document
elicited
exciting
exciting light
fiberoptic
fluorescence
gauge
human
human lens
identified
indicators
individual
instrumentation
lens
lenses
levels
light
measurements
measurements obtained
method
metrics
modest
noninvasive
norm
normal
normal human
obtained
ocular
ocular lens
oma-based
optical
optical properties
optical quality
overall
overall optical
processes
properties
quality
quantifying
quantifying optical
rapid
reference
relative
resulting
results
serve
set
signature
similar
spectra
subject
tool
typically
various
vivo
wavelengths