Three-dimensional scanning confocal laser microscope

Anderson, R. Rox; Webb, Robert H.; Rajadhyaksha, Milind

Three-dimensional scanning confocal laser microscope

Patent · Fri Jan 01 04:00:00 EST 1999

OSTI ID:872185

Anderson, R. Rox; Webb, Robert H.; Rajadhyaksha, Milind

A confocal microscope for generating an image of a sample includes a first scanning element for scanning a light beam along a first axis, and a second scanning element for scanning the light beam at a predetermined amplitude along a second axis perpendicular to the first axis. A third scanning element scans the light beam at a predetermined amplitude along a third axis perpendicular to an imaging plane defined by the first and second axes. The second and third scanning element are synchronized to scan at the same frequency. The second and third predetermined amplitudes are percentages of their maximum amplitudes. A selector determines the second and third predetermined amplitudes such that the sum of the percentages is equal to one-hundred percent.

Research Organization:: The General Hospital Corp., Boston, MA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-91ER61229

Assignee:: The General Hospital Corp. (Boston, MA)

Patent Number(s):: 5,880,880

Application Number:: 08/683,607

OSTI ID:: 872185

Country of Publication:: United States

Language:: English

References (9)

Optics for laser rasters Webb, Robert H. Applied Optics, Vol. 23, Issue 20 https://doi.org/10.1364/AO.23.003680	journal	January 1984
In vivo spatio-temporal visualization of the human skin by real-time confocal microscopy Bertrand, C.; Corcuff, P. Scanning, Vol. 16, Issue 3 https://doi.org/10.1002/sca.4950160301	journal	January 1994
In vivo imaging of human teeth and skin using real-time confocal microscopy: In vivo confocal microscopy New, K. C.; Petroll, W. M.; Boyde, A. Scanning, Vol. 13, Issue 5 https://doi.org/10.1002/sca.4950130507	journal	January 1991
The Optics of Human Skin Anderson, R. Rox; Parrish, John A. Journal of Investigative Dermatology, Vol. 77, Issue 1, p. 13-19 https://doi.org/10.1111/1523-1747.ep12479191	journal	July 1981
Scanning Laser Ophthalmoscope Webb, Robert H.; Hughes, George W. IEEE Transactions on Biomedical Engineering, Vol. BME-28, Issue 7 https://doi.org/10.1109/TBME.1981.324734	journal	July 1981
Flying spot TV ophthalmoscope Webb, R. H.; Hughes, G. W.; Pomerantzeff, O. Applied Optics, Vol. 19, Issue 17 https://doi.org/10.1364/AO.19.002991	journal	January 1980
Confocal scanning laser ophthalmoscope Webb, Robert H.; Hughes, George W.; Delori, Francois C. Applied Optics, Vol. 26, Issue 8 https://doi.org/10.1364/AO.26.001492	journal	January 1987
In vivo Vision of the Human Skin with the Tandem Scanning Microscope Corcuff, P.; Lévêque, J. -L. Dermatology, Vol. 186, Issue 1 https://doi.org/10.1159/000247302	journal	January 1993
Morphometry of human epidermis in vivo by real-time confocal microscopy Corcuff, P.; Bertrand, C.; Leveque, J. L. Archives of Dermatological Research, Vol. 285, Issue 8 https://doi.org/10.1007/BF00376820	journal	November 1993

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