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Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

Patent ·
OSTI ID:872168
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Columbia, MO
+ Show Author Affiliations

A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.

Research Organization:
University of Missouri
DOE Contract Number:
FG02-89ER60875
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Number(s):
US 5876693
OSTI ID:
872168
Country of Publication:
United States
Language:
English

References (12)

Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR n Q 3–n (n= 0,1, or 2; R = Me, Et, Bu t , or Ph; Q = CH 2 OCOMe or CH 2 OH) journal January 1973
Chemical and physical properties of radionuclides journal January 1987
Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling journal November 1992
Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3 journal July 1992
Coordination compounds in nuclear medicine journal May 1993
Tumour targeting with radiolabelled macrocycle–antibody conjugates journal January 1990
Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
  • Rao, T. N.; Gustavson, Linda M.; Srinivasan, Ananthachari
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 8 https://doi.org/10.1016/0883-2897(92)90175-X
journal November 1992
Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 journal July 1990
Aspects of the Chemistry of Technetium Phosphine Complexes journal January 1993
Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands journal September 1991
Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver journal January 1988
Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. journal June 1988

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combined
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functionalized
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hydroxyalkyl
hydroxyalkyl phosphine
ligand
metal
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method
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pharmaceutical comprises
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phosphine compounds
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