Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

Patent ·
OSTI ID:335471
; ; ; ; ;

This research discloses a compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand. 16 figs.

Research Organization:
University of Missouri
Sponsoring Organization:
USDOE, Washington, DC (United States)
DOE Contract Number:
FG02-89ER60875
Assignee:
Univ. of Missouri, Columbia, MO (United States)
Patent Number(s):
US 5,876,693/A/
Application Number:
PAN: 8-902,829
OSTI ID:
335471
Country of Publication:
United States
Language:
English

References (12)

Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR n Q 3–n (n= 0,1, or 2; R = Me, Et, Bu t , or Ph; Q = CH 2 OCOMe or CH 2 OH) journal January 1973
Chemical and physical properties of radionuclides journal January 1987
Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling journal November 1992
Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3 journal July 1992
Coordination compounds in nuclear medicine journal May 1993
Tumour targeting with radiolabelled macrocycle–antibody conjugates journal January 1990
Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands journal September 1991
Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
  • Rao, T. N.; Gustavson, Linda M.; Srinivasan, Ananthachari
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 8 https://doi.org/10.1016/0883-2897(92)90175-X
journal November 1992
Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 journal July 1990
Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver journal January 1988
Aspects of the Chemistry of Technetium Phosphine Complexes journal January 1993
Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. journal June 1988

Similar Records

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CHEMICAL PREPARATION
DRUGS
LIGANDS
METALS
PHOSPHINES
USES