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Title: Urea biosensor for hemodialysis monitoring

Abstract

An electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick.

Inventors:
 [1]
  1. (Livermore, CA)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
872091
Patent Number(s):
US 5858186
Assignee:
Regents of University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
urea; biosensor; hemodialysis; monitoring; electrochemical; sensor; capable; detecting; quantifying; fluids; resulting; procedures; based; measurement; ph; change; produced; aqueous; environment; products; enzyme-catalyzed; hydrolysis; fabricated; methods; amenable; mass; fabrication; low-cost; sensors; providing; potential; disposable; typical; application; treatment; centers; conjunction; appropriate; electronics; computer; determine; endpoint; utilized; allow; at-home; testing; dialysis; home; monitor; similar; principle; devices; blood; glucose; diabetics; require; droplet; sample; finger; prick; blood glucose; electrochemical sensor; chemical sensor; typical application; ph change; appropriate electronics; sensor capable; fluids resulting; hemodialysis procedures; /204/435/

Citation Formats

Glass, Robert S. Urea biosensor for hemodialysis monitoring. United States: N. p., 1999. Web.
Glass, Robert S. Urea biosensor for hemodialysis monitoring. United States.
Glass, Robert S. Fri . "Urea biosensor for hemodialysis monitoring". United States. https://www.osti.gov/servlets/purl/872091.
@article{osti_872091,
title = {Urea biosensor for hemodialysis monitoring},
author = {Glass, Robert S.},
abstractNote = {An electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

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