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Title: Urea biosensor for hemodialysis monitoring

Abstract

This research discloses an electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick. 9 figs.

Inventors:
Publication Date:
Research Org.:
University of California
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
321271
Patent Number(s):
US 5,858,186/A/
Application Number:
PAN: 8-777,682
Assignee:
Univ. of California, Oakland, CA (United States) PTO; SCA: 550600; 550200; PA: EDB-99:031776; SN: 99002064439
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 12 Jan 1999
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; UREA; ELECTROCHEMISTRY; DIALYSIS; DESIGN; MEASURING INSTRUMENTS; UROGENITAL SYSTEM DISEASES; KIDNEYS

Citation Formats

Glass, R.S. Urea biosensor for hemodialysis monitoring. United States: N. p., 1999. Web.
Glass, R.S. Urea biosensor for hemodialysis monitoring. United States.
Glass, R.S. Tue . "Urea biosensor for hemodialysis monitoring". United States.
@article{osti_321271,
title = {Urea biosensor for hemodialysis monitoring},
author = {Glass, R.S.},
abstractNote = {This research discloses an electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick. 9 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}