Method for improved selectivity in photo-activation of molecular agents

Fisher, Walter G; Wachter, Eric A; Dees, H Craig

Title: Method for improved selectivity in photo-activation of molecular agents

Patent · Thu Jan 01 00:00:00 EST 1998

OSTI ID:871945

Fisher, Walter G ^[1]; Wachter, Eric A ^[2]; Dees, H Craig ^[1]

Knoxville, TN
Oak Ridge, TN

A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

DOE Contract Number:: AC05-84OR21400

Assignee:: Photogen, Inc. (Knoxville, TN)

Patent Number(s):: US 5829448

OSTI ID:: 871945

Country of Publication:: United States

Language:: English

References (57)

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improved
selectivity
photo-activation
molecular
agents
treatment
particular
volume
plant
animal
tissue
comprising
steps
treating
photo-active
agent
retains
portion
light
sufficient
promote
simultaneous
two-photon
excitation
retained
active
disclosed
cancer
producing
photo-activated
material
two-photon excitation
photo-activated molecular
simultaneous two-photon
photo-active molecular
molecular agent
animal tissue
particular volume
improved selectivity
molecular agents
tissue retains
tissue comprising
agent retained
light sufficient
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Title: Method for improved selectivity in photo-activation of molecular agents

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