Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Resonant-cavity apparatus for cytometry or particle analysis

Patent ·
OSTI ID:871776
 [1]
  1. Albuquerque, NM
+ Show Author Affiliations

A resonant-cavity apparatus for cytometry or particle analysis. The apparatus comprises a resonant optical cavity having an analysis region within the cavity for containing one or more biological cells or dielectric particles to be analyzed. In the presence of a cell or particle, a light beam in the form of spontaneous emission or lasing is generated within the resonant optical cavity and is encoded with information about the cell or particle. An analysis means including a spectrometer and/or a pulse-height analyzer is provided within the apparatus for recovery of the information from the light beam to determine a size, shape, identification or other characteristics about the cells or particles being analyzed. The recovered information can be grouped in a multi-dimensional coordinate space for identification of particular types of cells or particles. In some embodiments of the apparatus, the resonant optical cavity can be formed, at least in part, from a vertical-cavity surface-emitting laser. The apparatus and method are particularly suited to the analysis of biological cells, including blood cells, and can further include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

Research Organization:
SANDIA CORP
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
US 5793485
OSTI ID:
871776
Country of Publication:
United States
Language:
English

References (9)

Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology journal September 1992
Intracavity spectroscopy in vertical cavity surface‐emitting lasers for micro‐optical‐mechanical systems journal September 1996
Vertical cavity surface-emitting laser scanning cytometer for high-speed analysis of cells conference April 1996
Semiconductor microlasers: A new approach to cell–structure analysis journal August 1996
The Blood book January 1983
Lasers and fiber optics in medicine conference June 1993
Optical trapping and manipulation of single cells using infrared laser beams journal December 1987
Surface-emitting semiconductor laser spectroscopy and microscopy for characterizing normal and sickled red blood cells conference April 1995
Surface-emitting semiconductor laser for intracavity spectroscopy and microscopy report March 1995

Similar Records

Related Subjects

/356/
analysis
analysis region
analyzed
analyzer
apparatus
apparatus comprise
apparatus comprises
beam
biological
biological cell
biological cells
blood
blood cell
blood cells
cavity
cavity surface
cell
cells
characteristics
comprises
containing
coordinate
cytometry
determine
dielectric
embodiments
emission
emitting laser
encoded
eradicating
form
formed
generated
height analyzer
identification
including
information
laser
lasing
light
light beam
manipulating
means
means including
method
multi-dimensional
optical
optical cavity
particle
particle analysis
particles
particular
particular type
particularly
particularly suited
presence
processing
processing means
provided
pulse-height
recovered
recovery
region
resonant
resonant optical
resonant-cavity
resonant-cavity apparatus
shape
size
sorting
space
spectrometer
spontaneous
spontaneous emission
suited
surface-emitting
surface-emitting laser
types
vertical-cavity
vertical-cavity surface-emitting