skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells

Patent ·
OSTI ID:870852
 [1];  [2]
  1. 12508 Loyola, NE., Albuquerque, NM 87112
  2. 7509 Spring Lake Dr., Apt. B1, Bethesda, MD 20817
+ Show Author Affiliations

An apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

Research Organization:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
DOE Contract Number:
AC04-94AL85000
Assignee:
Gourley, Paul L. (12508 Loyola, NE., Albuquerque, NM 87112);Gourley, Mark F. (7509 Spring Lake Dr., Apt. B1, Bethesda, MD 20817)
Patent Number(s):
US 5608519
OSTI ID:
870852
Country of Publication:
United States
Language:
English

References (4)

Lasers and fiber optics in medicine conference June 1993
Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology journal September 1992
The Blood book January 1983
Optical trapping and manipulation of single cells using infrared laser beams journal December 1987

Similar Records

Related Subjects

laser
apparatus
method
microscopic
spectroscopic
analysis
processing
biological
cells
comprises
region
cavity
containing
analyzed
presence
cell
superposition
activated
portion
medium
encode
information
beam
recoverable
means
preferably
array
photodetector
ccd
camera
spectrometer
analyze
biomedical
including
blood
manipulating
sorting
eradicating
analysis region
ccd camera
spectroscopic analysis
laser cavity
blood cells
apparatus comprises
laser beam
biological cells
laser apparatus
processing means
blood cell
apparatus comprise
activated portion
biological cell
/356/250/