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Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells

Patent ·
OSTI ID:870852
 [1];  [2]
  1. 12508 Loyola, NE., Albuquerque, NM 87112
  2. 7509 Spring Lake Dr., Apt. B1, Bethesda, MD 20817
+ Show Author Affiliations

An apparatus and method for microscopic and spectroscopic analysis and processing of biological cells. The apparatus comprises a laser having an analysis region within the laser cavity for containing one or more biological cells to be analyzed. The presence of a cell within the analysis region in superposition with an activated portion of a gain medium of the laser acts to encode information about the cell upon the laser beam, the cell information being recoverable by an analysis means that preferably includes an array photodetector such as a CCD camera and a spectrometer. The apparatus and method may be used to analyze biomedical cells including blood cells and the like, and may include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

Research Organization:
SANDIA CORP
DOE Contract Number:
AC04-94AL85000
Assignee:
Gourley, Paul L. (12508 Loyola, NE., Albuquerque, NM 87112);Gourley, Mark F. (7509 Spring Lake Dr., Apt. B1, Bethesda, MD 20817)
Patent Number(s):
US 5608519
OSTI ID:
870852
Country of Publication:
United States
Language:
English

References (4)

Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood rheology journal September 1992
The Blood book January 1983
Lasers and fiber optics in medicine conference June 1993
Optical trapping and manipulation of single cells using infrared laser beams journal December 1987

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