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Triggered pore-forming agents

Patent ·
OSTI ID:871686
An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.
Research Organization:
Worcester Foundation
DOE Contract Number:
FG02-90ER20018
Assignee:
Worcester Foundation for Experimental Biology (Shrewsbury, MA)
Patent Number(s):
US 5777078
OSTI ID:
871686
Country of Publication:
United States
Language:
English

References (51)

Subunit stoichiometry of staphylococcal alpha-hemolysin in crystals and on membranes: a heptameric transmembrane pore. journal December 1994
Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46. journal January 1984
Functional complementation of staphylococcal alpha-hemolysin fragments. Overlaps, nicks, and gaps in the glycine-rich loop. journal March 1993
Surface labeling of key residues during assembly of the transmembrane pore formed by staphylococcal α-hemolysin journal December 1994
Genetically Engineered Pores as Metal Ion Biosensors journal January 1993
Restoration of pore-forming activity in staphylococcal α-hemolysin by targeted covalent modification journal January 1995
A photogenerated pore-forming protein journal June 1995
Self-assembling biomolecular materials in mediaine journal October 1994
Tumor targeting: Activation of prodrugs by enzyme-monoclonal antibody conjugates journal June 1994
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules journal October 1993
Antibacterial peptides: Key components needed in immunity journal April 1991
Halothane acts on many potassium channels, including a minimal potassium channel journal October 1993
Triggeps and switches in a self-assembling pore-forming portein journal October 1994
Controlling Cell Chemistry with Caged Compounds journal October 1993
Functional expression of the alpha-hemolysin of Staphylococcus aureus in intact Escherichia coli and in cell lysates. Deletion of five C-terminal amino acids selectively impairs hemolytic activity. journal May 1992
Channels With Single Transmembrane Segments journal February 1994
Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol journal April 1993
Site-specific incorporation of novel backbone structures into proteins journal January 1992
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma journal October 1994
DNA-like double helix formed by peptide nucleic acid journal April 1994
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation journal January 1991
Photoactivation of toxin conjugates journal March 1992
The Activation of Human Type IV Collagenase Proenzyme journal January 1989
A new immunotoxin built by linking a hemolytic toxin to a monoclonal antibody specific for immature T lymphocytes journal October 1988
Differential phosphorylation of neuronal substrates by catalytic subunits of Aplysia cAMP-dependent protein kinase with alternative N termini. journal September 1994
Extending the chemistry of enzymes and abzymes journal January 1991
Synthesis of proteins by native chemical ligation journal November 1994
A pore-forming protein with a metal-actuated switch journal January 1994
Photoactivatable drugs journal April 1987
Biochemical and Cytotoxic Properties of Conjugates of Transferrin with Equinatoxin II, a Cytolysin from a Sea Anemone journal March 1995
Genetically-Engineered Protease-Activated Triggers in a Pore-Forming Protein journal January 1993
Photocleavable biotin derivatives: a versatile approach for the isolation of biomolecules. journal August 1995
Theoretical models of the ion channel structure of amyloid beta-protein journal December 1994
Novel Photocleavable Protein Crosslinking Reagents and Their use in the Preparation of Antibody-Toxin Conjugates journal September 1985
Cyclin-dependent kinases: regulators of the cell cycle and more journal December 1994
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide journal December 1991
Tolerogenic conjugates of xenogeneic monoclonal antibodies with monomethoxypolyethylene glycol. I. Induction of long-lasting tolerance to xenogeneic monoclonal antibodies journal January 1988
Supramolecular surfactants: Amphiphilic polymers designed to disrupt lipid membranes journal March 1989
A carcinoembryonic antigen-directed immunotoxin built by linking a monoclonal antibody to a hemolytic toxin journal May 1989
Photocleavable Nitrobenzyl-Protein Conjugates journal June 1994
Type II regulatory subunits of cAMP-dependent protein kinase and their binding proteins in the nervous system of Aplysia californica. journal January 1994
[3] Protein engineering of single-chain Fv analogs and fusion proteins book January 1991
A general method for site-specific incorporation of unnatural amino acids into proteins journal April 1989
Molecular design gets into a hole journal February 1992
Assembly of the oligomeric membrane pore formed by Staphylococcal alpha-hemolysin examined by truncation mutagenesis. journal October 1992
Photocleavable Biotinylated Ligands for Affinity Chromatography journal May 1994
Controlling Life's Gateway journal September 1994
An intermediate in the assembly of a pore-forming protein trapped with a genetically-engineered switch journal February 1995
A Pore-forming protein with a protease-activated trigger journal January 1994
Immunotoxins journal December 1986
Secondary structure and assembly mechanism of an oligomeric channel protein journal April 1985

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