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Title: Nuclear magnetic resonance contrast agents

Patent ·
OSTI ID:871291
 [1];  [1];  [1];  [1]
  1. Los Alamos, NM
+ Show Author Affiliations

A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC.sub.16 H.sub.14 N.sub.6. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
DOE Contract Number:
W-7405-ENG-36
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Number(s):
US 5702683
OSTI ID:
871291
Country of Publication:
United States
Language:
English

References (11)

Paramagnetic macrocyclic complexes as contrast agents for MR imaging: proton nuclear relaxation rate enhancement in aqueous solution and in rat tissues. journal May 1986
Preparation and properties of complexes of lanthanides with a hexadentate nitrogen-donor macrocycle: X-ray crystal structure of the complex [La(NO3)3l] journal January 1979
The synthesis of macrocyclic lanthanide complexes derived from 2,5-furandialdehyde and α,ω-alkanediamines journal February 1984
Hexaaza macrocyclic complexes of the lanthanides journal May 1986
Metal-templated synthesis of novel macrocyclic complexes of the uranyl ion journal July 1985
The template synthesis and characterization of hexaaza 18-membered macrocyclic complexes of cerium(III), praseodymium(III) and neodymium(III) nitrates journal May 1985
Lanthanide complexes of some macrocyclic schiff bases derived from pyridine-2,6-dicarboxaldehyde α,ω-primary diamines journal September 1984
Synthesis and structure of lanthanide complexes of a mixed donor macrocyclic ligand journal May 1985
The template synthesis and crystal and molecular structure of a sexidentate Schiff-base macrocyclic complex of samarium( III ), [Sm(C 18 H 18 N 6 )(NO 3 )(OH)(H 2 O)]NO 3 ·2MeOH journal January 1984
Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design journal October 1987
Highly stable lanthanide macrocyclic complexes: in search of new contrast agents for NMR imaging journal January 1988

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Related Subjects

nuclear
magnetic
resonance
contrast
agents
family
imaging
method
enhancing
images
incorporating
agent
prior
forming
formation
paramagnetic
lanthanide
hexaazamacrocyclic
molecule
basic
example
formula
lnc
16
14
applications
medical
diagnosis
treatment
portions
human
formed
means
techniques
resonance imaging
magnetic resonance
nuclear magnetic
resonance techniques
medical diagnosis
contrast agents
contrast agent
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