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Nuclear magnetic resonance contrast agents

Patent ·
OSTI ID:871291
 [1];  [1];  [1];  [1]
  1. Los Alamos, NM
+ Show Author Affiliations

A family of contrast agents for use in magnetic resonance imaging and a method of enhancing the contrast of magnetic resonance images of an object by incorporating a contrast agent of this invention into the object prior to forming the images or during formation of the images. A contrast agent of this invention is a paramagnetic lanthanide hexaazamacrocyclic molecule, where a basic example has the formula LnC.sub.16 H.sub.14 N.sub.6. Important applications of the invention are in medical diagnosis, treatment, and research, where images of portions of a human body are formed by means of magnetic resonance techniques.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM
DOE Contract Number:
W-7405-ENG-36
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Number(s):
US 5702683
OSTI ID:
871291
Country of Publication:
United States
Language:
English

References (11)

Lanthanide complexes of some macrocyclic schiff bases derived from pyridine-2,6-dicarboxaldehyde α,ω-primary diamines journal September 1984
Hexaaza macrocyclic complexes of the lanthanides journal May 1986
Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design journal October 1987
The template synthesis and characterization of hexaaza 18-membered macrocyclic complexes of cerium(III), praseodymium(III) and neodymium(III) nitrates journal May 1985
Highly stable lanthanide macrocyclic complexes: in search of new contrast agents for NMR imaging journal January 1988
Metal-templated synthesis of novel macrocyclic complexes of the uranyl ion journal July 1985
The template synthesis and crystal and molecular structure of a sexidentate Schiff-base macrocyclic complex of samarium( III ), [Sm(C 18 H 18 N 6 )(NO 3 )(OH)(H 2 O)]NO 3 ·2MeOH journal January 1984
The synthesis of macrocyclic lanthanide complexes derived from 2,5-furandialdehyde and α,ω-alkanediamines journal February 1984
Preparation and properties of complexes of lanthanides with a hexadentate nitrogen-donor macrocycle: X-ray crystal structure of the complex [La(NO3)3l] journal January 1979
Paramagnetic macrocyclic complexes as contrast agents for MR imaging: proton nuclear relaxation rate enhancement in aqueous solution and in rat tissues. journal May 1986
Synthesis and structure of lanthanide complexes of a mixed donor macrocyclic ligand journal May 1985

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