Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, spect and pet imaging
Patent
·
OSTI ID:871006
- Fairfax, VA
- Stony Brook, NY
- Setauket, NY
A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.
- Research Organization:
- ASSOC UNIVERSITIES INC
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Associated Universities, Inc. (Washington, DC)
- Patent Number(s):
- US 5639879
- Application Number:
- 08/382,522
- OSTI ID:
- 871006
- Country of Publication:
- United States
- Language:
- English
Synthesis of a kinetically stable yttrium-90 labelled macrocycle–antibody conjugate
|
journal | January 1989 |
Nuclear magnetic resonance spectroscopy of lanthanide complexes with a tetraacetic tetraaza macrocycle. Unusual conformation properties
|
journal | May 1980 |
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Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, SPECT and PET imaging
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-tetraacetic acid
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11-tetraazacyclotetradecane
acetic acid
acid
antibodies
antibody
biological
biological molecules
carboxylates
compounds
conjugated
conjugates
cyanomethylating
form
functionalized
hydrolyzing
imaging
including
involves
labeled
macrocyclic
macrocyclic compounds
macrocyclic polyaminocarboxylates
method
molecules
molecules including
monoclonal
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polyaminocarboxylates
radiometal
radiometal antibody
radiometals
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simple
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tetranitrile
therapy
various
various biological