Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging

Mease, Ronnie C; Mausner, Leonard F; Srivastava, Suresh C

Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging

Patent · Tue Jun 27 00:00:00 EDT 1995

OSTI ID:869952

Mease, Ronnie C ^[1]; Mausner, Leonard F ^[2]; Srivastava, Suresh C ^[3]

Fairfax, VA
Stony Brook, NY
Setauket, NY

A simple method for the synthesis of 1,4,7,10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.

Research Organization:: ASSOC UNIVERSITIES INC

DOE Contract Number:: AC02-76CH00016

Assignee:: Associated Universities, Inc. (Washington, DC)

Patent Number(s):: US 5428156

Application Number:: 08/042,249

OSTI ID:: 869952

Country of Publication:: United States

Language:: English

References (11)

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Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging

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