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Title: Erythropoietin binding protein from mammalian serum

Patent ·
OSTI ID:870923

Purified mammalian erythropoietin binding-protein is disclosed, and its isolation, identification, characterization, purification, and immunoassay are described. The erythropoietin binding protein can be used for regulation of erythropoiesis by regulating levels and half-life of erythropoietin. A diagnostic kit for determination of level of erythropoietin binding protein is also described.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents, University of California (Oakland, CA)
Patent Number(s):
US 5625035
OSTI ID:
870923
Country of Publication:
United States
Language:
English

References (7)

Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin journal October 1991
Age-Related Differences in Erythropoietic Response to Recombinant Human Erythropoietin: Comparison in Adult and Infant Rhesus Monkeys journal December 1990
Recombinant Erythopoietin in Pediatrics: A Clinical Perspective journal March 1990
Expression cloning of the murine erythropoietin receptor journal April 1989
Recombinant Human Erythropoietin: Physiology, Pathophysiology of Anemia in Renal Failure, and Economic Aspects Related to Dosing journal January 1990
Characterization of three erythropoietin (Epo)-binding proteins in various human Epo-responsive cell lines and in cells transfected with human Epo-receptor cDNA [see comments] journal January 1995
Recombinant Human Erythropoietin: Implications for Nephrology journal March 1988