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Single step signal group-imidazole labeling of organic phosphate groups under aqueous conditions

Patent ·
OSTI ID:870396
;

Compounds and methods for single step, covalent labeling of the phosphate group of an organic substance under aqueous conditions are described. The labeling compound includes any kind of detectable signal group covalently bound to an imidazole moiety, which can be imidazole or a substituted imidazole. A preferred labeling compound has the formula ##STR1##

Research Organization:
Northeastern University, Boston, MA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-90ER60964
Assignee:
Northeastern University (Boston, MA)
Patent Number(s):
5,512,486
Application Number:
08/060,569
OSTI ID:
870396
Country of Publication:
United States
Language:
English

References (5)

Nitrogen-bound and carbon-bound imidazole complexes of ruthenium ammines journal January 1974
Solution-phase detection of polynucleotides using interacting fluorescent labels and competitive hybridization journal December 1989
Derivatization of unprotected polynucleotides journal January 1983
Modification of Oligo (Poly) Nucleotide Phosphomonoester Groups in Aqueous Solutions journal December 1987
Preparation of ethylenediaminephosphoramidates of nucleotides and derivatization with fluorescein isothiocyanate journal July 1990

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Related Subjects

/436/999/
aqueous
aqueous conditions
bound
compound
compounds
conditions
covalent
covalently
covalently bound
described
detectable
formula
group-imidazole
imidazole
labeling
methods
moiety
organic
organic phosphate
organic substance
phosphate
preferred
signal
single
single step
step
str1
substance
substituted