Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa

Patent · 31 December 1995

OSTI ID:870385

Satyamurthy, Nagichettiar ^[1]; Barrio, Jorge R ^[2]; Bishop, Allyson J ^[3]; Namavari, Mohammad ^[1]; Bida, Gerald T ^[4]

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1. Los Angeles, CA
2. Agoura Hills, CA
3. Wahnemuhle, DE
4. Shreveport, LA

A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb.sub.3 ; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to .ltoreq.7.

• Research Organization: University of California
• DOE Contract Number: FC03-87ER60615
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5510522
• OSTI ID: 870385
• Country of Publication: United States
• Language: English

Related Subjects

-l-phenylalanine
-l-phenylalanine ethyl
/999/
18
4-di-t-butoxycarbonyloxy-6-
6-
6-fluoro
acetic acid
acid
attached
bb
benzene
compound
compounds
comprising
derivative
dit-butyldicarbonate
ester
ethyl
ethyl ester
family
fluoro
fluoro-1-dopa
followed
forming
hexamethyltin
hydrobromic
iodine
l-dopa
ltoreq
n-formyl-3
ph
process
protected
protecting
radiofluorodestannylation
raising
reacting
regioselective
regioselective radiofluorodestannylation
serially
silver
steps
synthesis
trifluoroacetic
trimethylstannyl