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Title: Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa

Patent ·
OSTI ID:224981
; ; ; ;

A process is revealed for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb{sub 3}; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to {<=}7. 1 fig.

Research Organization:
Univ. of California (United States)
DOE Contract Number:
FC03-87ER60615
Assignee:
Univ. of California, Oakland, CA (United States)
Patent Number(s):
US 5,510,522/A/
Application Number:
PAN: 8-393,428; CNN: Grant PO1-NS-15654;Grant RO1-MH-37916
OSTI ID:
224981
Resource Relation:
Other Information: PBD: 23 Apr 1996
Country of Publication:
United States
Language:
English

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Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
FLUORINE 18
TRACER TECHNIQUES
NUCLEAR MEDICINE