Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[{sup 18}F]fluoro-1-dopa
Patent
·
OSTI ID:224981
A process is revealed for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb{sub 3}; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to {<=}7. 1 fig.
- Research Organization:
- University of California
- DOE Contract Number:
- FC03-87ER60615
- Assignee:
- Univ. of California, Oakland, CA (United States)
- Patent Number(s):
- US 5,510,522/A/
- Application Number:
- PAN: 8-393,428; CNN: Grant PO1-NS-15654; Grant RO1-MH-37916
- OSTI ID:
- 224981
- Country of Publication:
- United States
- Language:
- English
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Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6-[.sup.18 F]fluoro-L-dopa
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