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Colloidal-gold electrosensor measuring device

Patent ·
OSTI ID:870163
 [1];  [2];  [2];  [1];  [3];  [1];  [2];  [2];  [4]
  1. Chapel Hill, NC
  2. Durham, NC
  3. Cary, NC
  4. Carrboro, NC
+ Show Author Affiliations

The present invention provides a new device for use in measuring lead levels in biological and environmental samples. Using square wave coulometry and colloidal gold particles impregnated on carbon electrodes, the present invention provides a rapid, reliable, portable and inexpensive means of detecting low lead levels. The colloidal gold modified electrodes have microelectrode array characteristics and produce significantly higher stripping detection signals for lead than are produced at bulk gold electrode surfaces. The method is effective in determining levels of lead down to at least 5 .mu.g/dL in blood samples as small as 10 .mu.L.

Research Organization:
Andcare, Inc. (Durham, NC)
DOE Contract Number:
FG05-94ER81657
Assignee:
Andcare, Inc. (Durham, NC)
Patent Number(s):
US 5468366
OSTI ID:
870163
Country of Publication:
United States
Language:
English

References (8)

Studies on acetylcholine sensor and its analytical application based on the inhibition of cholinesterase journal January 1990
The conformation of γ-globulin adsorbed on polystyrene latices determined by quasielastic light scattering journal July 1978
Studies of protein adsorption on polystyrene latex surfaces journal October 1980
Sensitive colloidal metal (gold or silver) staining of protein blots on nitrocellulose membranes journal March 1985
Determination of lead in whole blood with a simple flow-injection system and computerized stripping potentiometry journal January 1988
Applications of enzyme-catalysed reactions in trace analysis—VII☆Determination of lead and indium by their inhibition of isocitrate dehydrogenase journal June 1974
The Reduction of Chlorine on Carbon in AlCl[sub 3]-KCl-NaCl Melts journal January 1972
Inhibited enzyme electrodes. Part 3: A sensor for low levels of H2S and HCN journal January 1990

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