Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water

Ferrieri, Richard A; Schlyer, David J; Shea, Colleen

Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water

Patent · Tue Jun 13 00:00:00 EDT 1995

OSTI ID:869932

Ferrieri, Richard A ^[1]; Schlyer, David J ^[2]; Shea, Colleen ^[3]

Patchogue, NY
Bellport, NY
Wading River, NY

A process for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- for radiotracer synthesis is disclosed. The process includes producing [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- simultaneously by exposing a low-enriched (20%-30%) [.sup.18 O]H.sub.2 O target to proton irradiation, sequentially isolating the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- from the [.sup.18 O]H.sub.2 O target, and reducing the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- to [.sup.13 N]NH.sub.3. The [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [.sup.18 O]H.sub.2 O, and sequential elution of [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [ .sup.18 F]F.sup.- fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- from a single irradiation of a single low-enriched [.sup.18 O]H.sub.2 O target.

Research Organization:: ASSOC UNIVERSITIES INC

DOE Contract Number:: AC02-76CH00016

Assignee:: Associated Universities, Inc. (Washington, DC)

Patent Number(s):: US 5425063

Application Number:: 08/042,741

OSTI ID:: 869932

Country of Publication:: United States

Language:: English

References (5)

« Les besoins d'emploi : contenu et problèmes posés par leur satisfaction » (à propos d'un article de R. Salais) Mériaux, Bernard Revue économique, Vol. 29, Issue 4 https://doi.org/10.3406/reco.1978.408408	journal	January 1978
Recommendation for a practical production of [2-18F]fluoro-2-deoxy-D-glucose Coenen, H. H.; Pike, V. W.; Stöcklin, G. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 38, Issue 8 https://doi.org/10.1016/0883-2889(87)90124-9	journal	January 1987
Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a potential brain-scanning agent Irie, Toshiaki; Fukushi, Kiyoshi; Inoue, Osame The International Journal of Applied Radiation and Isotopes, Vol. 33, Issue 8 https://doi.org/10.1016/0020-708X(82)90061-8	journal	August 1982
[18F]fluoride production with a circulating [18O]water target Iwata, Ren; Ido, Tatsuo; Brady, Frank International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 38, Issue 11 https://doi.org/10.1016/0883-2889(87)90272-3	journal	January 1987
Production of radionuclides and labelled compounds from accelerators: Report of an international atomic energy agency consultants meeting Servian, Jorge L. The International Journal of Applied Radiation and Isotopes, Vol. 26, Issue 12, p. 763-770 https://doi.org/10.1016/0020-708X(75)90136-2	journal	January 1975

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Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water

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References (5)

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