Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography

Title: Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography

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Abstract

A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.

Inventors:

Ferrieri, Richard A ^[1]; Schlyer, David J ^[2]; Alexoff, David ^[3]

Patchogue, NY
Bellport, NY
Westhampton, NY

Publication Date:: 1996-01-09

Research Org.:: Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:: 870246

Patent Number(s):: US 5482865

Application Number:: 08/258,053

Assignee:: Associated Universities, Inc. (Washington, DC)

DOE Contract Number:: AC02-76CH00016

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: apparatus; method; preparing; oxygen-15; labeled; water; 15; injectable; form; positron; emission; tomography; handling; processing; preferably; produced; irradiating; flowing; gas; target; nitrogen; hydrogen; collector; receiving; directing; containing; impurities; mainly; ammonia; nh; sterile; trap; ammonium; device; displacing; cation; resin; removes; combining; saline; solution; produces; delivering; syringe; injection; patient; disclosed; neither; requires; isotopic; exchange; reaction; nor; application; temperature; saline solution; gas containing; emission tomography; positron emission; water containing; processing apparatus; flowing gas; exchange reaction; oxygen-15 labeled; gas target; injectable form; preparing oxygen-15; labeled water; /436/250/376/422/

Citation Formats


                    Ferrieri, Richard A, Schlyer, David J, and Alexoff, David. Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography.  United States: N. p., 1996. 
        Web.

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                    Ferrieri, Richard A, Schlyer, David J, & Alexoff, David. Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography.  United States.

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                    Ferrieri, Richard A, Schlyer, David J, and Alexoff, David. Tue .  
        "Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography".  United States.  https://www.osti.gov/servlets/purl/870246.

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@article{osti_870246,

  title        = {Apparatus and method for preparing oxygen-15 labeled water H.sub.2 [.sup.15 O] in an injectable form for use in positron emission tomography},

  author       = {Ferrieri, Richard A and Schlyer, David J and Alexoff, David},

  abstractNote = {A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/870246},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1996},

  month        = {1}

}

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