Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung

Patent ·
OSTI ID:869755
 [1];  [2];  [2]
  1. Germantown, MD
  2. Grand Junction, CO
+ Show Author Affiliations

Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM
DOE Contract Number:
W-7405-ENG-36
Assignee:
University of California Office of Technology Transfer (Alameda, CA)
Patent Number(s):
US 5391547
OSTI ID:
869755
Country of Publication:
United States
Language:
English

References (2)

Preparation and characterization of copper-67 porphyrin-antibody conjugates journal December 1987
Early Detection of Lung Cancer by Means of Hematoporphyrin Derivative Fluorescence and Laser Photoradiation journal June 1985

Similar Records

Related Subjects

/514/424/
10
15
20-tetrakis
4-carboxyphenyl
67
analysis
beta
beta radiation
cancers
characteristics
complex
computed
computed tomography
copper
copper-64
cu
destruction
emission
emission computed
emission tomography
emitter
example
fluorescent
fluorescent tracer
gamma
gamma radiation
image
image analysis
isotope
latter
lighter
locate
lung
malignancies
malignant
malignant tissue
mass
method
particular
photon
photon emission
porphine
porphyrins
positron
positron emission
positron emitter
provides
radiation
radiotracer
selective
single
single photon
situs
source
substituted
techniques
tetra-aryl
tetra-aryl porphyrins
tissue
tissue mass
tomography
tomography techniques
tracer
treating
useful
vivo