Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung

Patent ·
OSTI ID:868533
 [1];  [2];  [3]
  1. 60 San Juan St., Los Alamos, NM 87544
  2. 694 Sperber La., Grand Junction, CO 81506
  3. 715 Victor Dr., Grand Junction, CO 81506
+ Show Author Affiliations

Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques cna be used to locate the malignant tissue mass.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM
DOE Contract Number:
W-7405-ENG-36
Assignee:
Cole, Dean A. (60 San Juan St., Los Alamos, NM 87544);Moody, III, David C. (402 Pine Tree La., Boulder, CO 80304);Ellinwood, L. Edward (694 Sperber La., Grand Junction, CO 81506);Klein, M. Gerard (715 Victor Dr., Grand Junction, CO 81506)
Patent Number(s):
US 5162231
OSTI ID:
868533
Country of Publication:
United States
Language:
English

References (4)

The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin journal April 1979
Cellular Uptake of Hydroxyethylvinyldeuteroporphyrin(Hvd) and Photoinactivation of Cultivated Human Leukemia (Reh6) Cells journal June 1986
A change in the quantum yield of photoinactivation of cells observed during photodynamic treatment journal March 1988
Subcellular Localization of Hematoporphyrin Derivative in Bladder Tumor Cells in Culture journal April 1990

Similar Records

Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
Patent · Mon Nov 09 23:00:00 EST 1992 · OSTI ID:7117152
Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung
Patent · Sat Dec 31 23:00:00 EST 1994 · OSTI ID:869755
Potentiation of radiation-induced cell kill by synthetic metalloporphyrins
Journal Article · Fri Mar 31 23:00:00 EST 1989 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6069151

Related Subjects

/436/376/435/514/
10
15
20-tetrakis
4-carboxyphenyl
67
analysis
beta
beta radiation
cancers
carboxyphenyl
characteristics
cna
complex
computed
computed tomography
copper
copper-64
cu
destruction
detecting
emission
emission computed
emission tomography
emitter
example
fluorescent
fluorescent tracer
gamma
gamma radiation
image
image analysis
isotope
latter
lighter
locate
lung
malignancies
malignant
malignant tissue
mass
method
particular
photon
photon emission
porphine
porphyrins
positron
positron emission
positron emitter
provides
radiation
radiotracer
selective
single
single photon
situs
source
substituted
techniques
tetra-aryl
tetra-aryl porphyrins
tissue
tissue mass
tomography
tomography techniques
tracer
useful
vivo