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Stable radiometal antibody immunoconjugates

Patent ·
OSTI ID:869422
 [1];  [2];  [3]
  1. Coram, NY
  2. Setauket, NY
  3. Oudon, FR
+ Show Author Affiliations

The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.

Research Organization:
ASSOC UNIVERSITIES INC
DOE Contract Number:
AC02-76CH00016
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Number(s):
US 5334729
OSTI ID:
869422
Country of Publication:
United States
Language:
English

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Related Subjects

/999/
antibody
antibody immunoconjugates
chelates
chelating
chelating structures
cyclohexyl
cyclohexyl dtpa
cyclohexyl edta
cyclohexyl polyaminocarboxylate
derivatives
dtpa
edta
edta monohydride
forms
immunoconjugates
labeled
labeled immunoconjugates
materials
methods
monohydride
polyaminocarboxylate
polyaminocarboxylate materials
preparing
preparing radiometal
radiometal
radiometal antibody
radiometal labeled
relates
rigid
rigid chelating
stable
stable radiometal
structures
trans
ttha