Method to directly radiolabel antibodies for diagnostic imaging and therapy

Patent · Tue Jan 01 00:00:00 EST 1991

OSTI ID:867794

Thakur, Mathew L ^[1]

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1. Cherry Hill, NJ

The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
• DOE Contract Number: AC04-76
• Assignee: Thomas Jefferson University (Philadelphia, PA)
• Patent Number(s): US 5011676
• OSTI ID: 867794
• Country of Publication: United States
• Language: English

Related Subjects

method
directly
radiolabel
antibodies
diagnostic
imaging
therapy
novel
kit
radiolabeling
proteins
antibody
fragments
therapeutic
purposes
comprises
incubating
protein-containing
solution
sodium
ascorbate
adding
required
quantity
reduced
radionuclide
incubated
protein
provided
reducing
agents
lyophilized
form
reducing agents
therapeutic purposes
method comprises
reducing agent
novel method
antibody fragment
method comprise
diagnostic imaging
radiolabel antibodies
radiolabeling proteins
containing solution
reduced radio
antibody fragments
directly radiolabeling
directly radiolabel
/530/