Method to directly radiolabel antibodies for diagnostic imaging and therapy

Patent · 31 December 1990

OSTI ID:867794

Thakur, Mathew L ^[1]

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1. Cherry Hill, NJ

The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA
• Assignee: Thomas Jefferson University (Philadelphia, PA)
• Patent Number(s): US 5011676
• OSTI ID: 867794
• Country of Publication: United States
• Language: English

Related Subjects

/530/
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