Continuous human cell lines and method of making same
Patent
·
OSTI ID:866860
- Oakland, CA
Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo[a]pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Number(s):
- US 4808532
- OSTI ID:
- 866860
- Country of Publication:
- United States
- Language:
- English
Similar Records
Continuous human cell lines and method of making same
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· Proc. Natl. Acad. Sci. U.S.A.; (United States)
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