Continuous human cell lines and method of making same
Patent
·
OSTI ID:5524665
Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.
- Research Organization:
- Lawrence Berkeley Lab., CA (USA)
- DOE Contract Number:
- AC03-76SF00098
- Assignee:
- Dept. of Energy
- Patent Number(s):
- None
- Application Number:
- ON: DE86013863
- OSTI ID:
- 5524665
- Country of Publication:
- United States
- Language:
- English
Similar Records
Continuous human cell lines and method of making same
Continuous human cell lines and method of making same
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene
Patent
·
Sat Dec 31 23:00:00 EST 1988
·
OSTI ID:866860
Continuous human cell lines and method of making same
Patent
·
Mon Feb 27 23:00:00 EST 1989
·
OSTI ID:7273127
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene
Journal Article
·
Sun Mar 31 23:00:00 EST 1985
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6331630
Related Subjects
550300 -- Cytology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOASSAY
BODY
CARCINOGEN SCREENING
CELL CULTURES
CELL PROLIFERATION
CLONE CELLS
CONDENSED AROMATICS
DESIGN
GLANDS
HYDROCARBONS
MAMMALS
MAMMARY GLANDS
MAN
MUTAGEN SCREENING
ORGANIC COMPOUNDS
ORGANS
PRIMATES
SCREENING
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOASSAY
BODY
CARCINOGEN SCREENING
CELL CULTURES
CELL PROLIFERATION
CLONE CELLS
CONDENSED AROMATICS
DESIGN
GLANDS
HYDROCARBONS
MAMMALS
MAMMARY GLANDS
MAN
MUTAGEN SCREENING
ORGANIC COMPOUNDS
ORGANS
PRIMATES
SCREENING
VERTEBRATES