Biomedical silver-109m isotope generator

Patent · Thu Jan 01 04:00:00 EST 1987

OSTI ID:866249

Wanek, Philip M ^[1]; Steinkruger, Frederick J ^[1]; Moody, David C ^[1]

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1. Los Alamos, NM

A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1.times.10.sup.-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• DOE Contract Number: W-7405-ENG-36
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4664892
• OSTI ID: 866249
• Country of Publication: United States
• Language: English

Related Subjects

-7
/423/250/252/422/976/
10
453
acceptable
acid
adjustment
administration
ag-109m
ag-109m-containing
apparatus
aqueous
ascorbic
biomedical
biomedical imaging
breakthrough
buffered
cd-109
column
composition
consisting
days
decays
dextrose
directly
eluate
eluent
eluted
equilibrium
exchange
exchange column
generator
half-life
human
imaging
imaging techniques
isotope
loaded
matter
means
medical imaging
method
minor
minutes
particulate
patient
permit
ph
phosphate
physiologically
physiologically acceptable
producing
producing substantially
pure
reached
secular
secular equilibrium
selectively
silver-109m
sodium
solution
substantially
substantially pure
sufficiently
techniques
thiosulfate
times
toxic