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Title: Biomedical silver-109m isotope generator

Abstract

A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1.times.10.sup.-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds.

Inventors:
 [1];  [1];  [1]
  1. Los Alamos, NM
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
866249
Patent Number(s):
US 4664892
Assignee:
United States of America as represented by United States (Washington, DC)
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
biomedical; silver-109m; isotope; generator; method; composition; matter; apparatus; producing; substantially; pure; ag-109m; imaging; techniques; cd-109; decays; half-life; 453; days; loaded; exchange; column; consisting; particulate; phosphate; secular; equilibrium; reached; minutes; selectively; eluted; means; physiologically; acceptable; aqueous; buffered; eluent; solution; sodium; thiosulfate; ascorbic; acid; dextrose; breakthrough; toxic; times; 10; -7; sufficiently; permit; administration; ag-109m-containing; eluate; minor; ph; adjustment; directly; human; patient; exchange column; substantially pure; secular equilibrium; producing substantially; medical imaging; physiologically acceptable; imaging techniques; biomedical imaging; /423/250/252/422/976/

Citation Formats

Wanek, Philip M, Steinkruger, Frederick J, and Moody, David C. Biomedical silver-109m isotope generator. United States: N. p., 1987. Web.
Wanek, Philip M, Steinkruger, Frederick J, & Moody, David C. Biomedical silver-109m isotope generator. United States.
Wanek, Philip M, Steinkruger, Frederick J, and Moody, David C. Thu . "Biomedical silver-109m isotope generator". United States. https://www.osti.gov/servlets/purl/866249.
@article{osti_866249,
title = {Biomedical silver-109m isotope generator},
author = {Wanek, Philip M and Steinkruger, Frederick J and Moody, David C},
abstractNote = {A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1.times.10.sup.-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds.},
doi = {},
url = {https://www.osti.gov/biblio/866249}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}

Patent:

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