Biomedical silver-109m isotope generator

Patent · Tue Mar 05 04:00:00 EST 1985

OSTI ID:5577795

Wanek, P M; Steinkruger, F J; Moody, D C

A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m, is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1 x 10-7, which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds. 1 fig.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• Assignee: Dept. of Energy
• Patent Number(s): None
• Application Number: ON: DE86013785
• OSTI ID: 5577795
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
CADMIUM 109
CADMIUM ISOTOPES
CHROMATOGRAPHY
DESIGN
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ION EXCHANGE CHROMATOGRAPHY
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
PH VALUE
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
SILVER 109
SILVER ISOTOPES
STABLE ISOTOPES
TIN COMPOUNDS
TIN PHOSPHATES
YEARS LIVING RADIOISOTOPES