Isotopic generator for bismuth-212 and lead-212 from radium

Patent · Thu Jan 01 00:00:00 EST 1987

OSTI ID:866241

Atcher, Robert W ^[1]; Friedman, Arnold M ^[2]; Hines, John ^[3]

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1. Kensington, MD
2. Park Forest, IL
3. Glen Ellyn, IL

A method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• DOE Contract Number: W-31109-ENG-38
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4663129
• OSTI ID: 866241
• Country of Publication: United States
• Language: English

Related Subjects

isotopic
generator
bismuth-212
lead-212
radium
method
apparatus
providing
radionuclides
thorium-228
carrier
solution
starting
material
input
radiologically
contained
portion
radium-224
separated
retained
strongly
basic
anion
exchange
column
transferred
accessible
acidic
cationic
retains
natural
radioactive
decay
generates
utilized
extraordinary
safety
measures
furthermore
provides
relatively
time
period
lived
useful
variety
medical
therapies
carrier solution
acidic cation
cationic exchange
exchange column
starting material
anion exchange
time period
radioactive decay
strongly acidic
isotopic generator
/423/250/252/976/