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Title: Isotopic generator for bismuth-212 and lead-212 from radium

Abstract

A method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.

Inventors:
 [1];  [2];  [3]
  1. Kensington, MD
  2. Park Forest, IL
  3. Glen Ellyn, IL
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
866241
Patent Number(s):
US 4663129
Assignee:
United States of America as represented by United States (Washington, DC)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
isotopic; generator; bismuth-212; lead-212; radium; method; apparatus; providing; radionuclides; thorium-228; carrier; solution; starting; material; input; radiologically; contained; portion; radium-224; separated; retained; strongly; basic; anion; exchange; column; transferred; accessible; acidic; cationic; retains; natural; radioactive; decay; generates; utilized; extraordinary; safety; measures; furthermore; provides; relatively; time; period; lived; useful; variety; medical; therapies; carrier solution; acidic cation; cationic exchange; exchange column; starting material; anion exchange; time period; radioactive decay; strongly acidic; isotopic generator; /423/250/252/976/

Citation Formats

Atcher, Robert W, Friedman, Arnold M, and Hines, John. Isotopic generator for bismuth-212 and lead-212 from radium. United States: N. p., 1987. Web.
Atcher, Robert W, Friedman, Arnold M, & Hines, John. Isotopic generator for bismuth-212 and lead-212 from radium. United States.
Atcher, Robert W, Friedman, Arnold M, and Hines, John. Thu . "Isotopic generator for bismuth-212 and lead-212 from radium". United States. https://www.osti.gov/servlets/purl/866241.
@article{osti_866241,
title = {Isotopic generator for bismuth-212 and lead-212 from radium},
author = {Atcher, Robert W and Friedman, Arnold M and Hines, John},
abstractNote = {A method and apparatus for providing radionuclides of bismuth-212 and lead-212. Thorium-228 and carrier solution starting material is input to a radiologically contained portion of an isotopic generator system, and radium-224 is separated from thorium-228 which is retained by a strongly basic anion exchange column. The separated radium-224 is transferred to an accessible, strongly acidic cationic exchange column. The cationic column retains the radium-224, and natural radioactive decay generates bismuth-212 and lead-212. The cationic exchange column can also be separated from the contained portion of the system and utilized without the extraordinary safety measures necessary in the contained portion. Furthermore, the cationic exchange column provides over a relatively long time period the short lived lead-212 and bismuth-212 radionuclides which are useful for a variety of medical therapies.},
doi = {},
url = {https://www.osti.gov/biblio/866241}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1987},
month = {1}
}

Patent:

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